Lima's first acting role was the wife, alongside Mickey Rourke and Forest Whitaker, in The Follow (2001), a short film in BMW's series The Hire, starring Clive Owen and directed by Wong Kar-wai. She also appeared with her fellow Angels in a guest spot playing herself in the series How I Met Your Mother in November 2007.
In 2008, Lima appeared on the American television series Ugly Betty, where she played herself and made friends with the series' title character, played by America Ferrera. According to her publicist, Liza Anderson, "Adriana has always been a huge fan of Ugly Betty and is thrilled for the opportunity to make a guest star appearance."